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- Ticrynafen Tienilic acid was found to act as a suicide substrate at the cytochrome P450 enzymes involved in drug metabolism. Unfortunately, the metabolic reaction ...1 KB (204 words) - 09:43, 11 August 2008
- Pharmacogenetics ... netic variations in CYP450s affect large populations. One member of the CYP450 superfamily, [[CYP2D6]], now has over 75 known allelic variations, some of ...7 KB (983 words) - 05:45, 21 August 2008
- Cimetidine Cimetidine is a known inhibitor of many [[isozyme]]s of the [[cytochrome P450]] enzyme system (specifically [[CYP1A2]], [[CYP2C9]], [[CYP2C19]], [[CYP2D ...8 KB (1141 words) - 05:03, 25 August 2008
- HB plot ... to oxidize their [[substrate]]s. [[CYP2B4]], a member of the [[cytochrome P450]] family is the only protein within this family, whose [[X-Ray structure]] ... [[Image:P450.jpg|frame|center|HB Plot and structure of Cytochrome P450 2B4 in closed form]]8 KB (1156 words) - 09:51, 17 September 2008
- Adverse drug reaction ... rug metabolism. Tables are available to check for drug interactions due to P450 interactions.<ref>{{cite web |url=http://medicine.iupui.edu/flockhart/ |ti ... =====Cytochrome P450=====10 KB (1362 words) - 09:55, 28 August 2008
- Drug interaction ... tabolic drug interactions is the enzyme system comprising the [[cytochrome P450 oxidase]]s. This system may be affected by either enzyme induction or enz ... * [http://medicine.iupui.edu/flockhart/table.htm Cytochome P450 table] maintained by the Indiana University School of Medicine5 KB (686 words) - 10:34, 28 August 2008
- Drug discovery hit to lead *not interfere with the [[P450]] enzymes nor with the [[P-glycoproteins]]4 KB (541 words) - 06:08, 17 September 2008
- Artemisinin ... evalonate pathway, expression of amorphadiene synthase, a novel cytochrome P450 monooxygenase (CYP71AV1) and its redox partner from A. annua. A three-step ...14 KB (2074 words) - 05:03, 10 October 2008
- Glutathione ... of ''N''-acetyl-''p''-benzoquinone imine (NAPQI), the reactive cytochrome P450-reactive metabolite formed by paracetamol (or acetaminophen as it is known ...6 KB (856 words) - 04:41, 24 October 2008
- Progestrone ... y PJ, Vonrhein C, Tickle IJ, Jhoti HCrystal structures of human cytochrome P450 3A4 bound to metyrapone and progesteroneScience v305, p.683-686 ... mental compounds, and drug molecules. The microsomal, membrane-associated, P450 isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2E1, and CYP1A2 are responsib ...8 KB (1073 words) - 09:35, 19 February 2009
- Ethinyl Estradiol ... It undergoes extensive metabolism in the liver involving the [[cytochrome P450]] 3A4 isoenzyme. EE and its metabolites are in excreted with the bile. Du ...12 KB (1540 words) - 09:12, 24 February 2009
- Dehydroepiandrosterone ... hrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage); then another enzyme, CYP17A1, converts pregneno ...20 KB (2812 words) - 08:55, 20 February 2009
- Pregnenolone ... e side-chain. The [[enzyme]] performing this task is [[P450 scc|cytochrome P450scc]], located in the [[mitochondria]], and controlled by pituitary tropic ...5 KB (687 words) - 09:34, 19 February 2009
- 17-Hydroxyprogesterone ... from [[progesterone]] via [[17-hydroxylase]], a [[Cytochrome P450 oxidase|P450c17 enzyme]], or from [[17-hydroxypregnenolone]] via 3β-hydroxysteroid deh ...7 KB (940 words) - 07:06, 31 October 2008
- Aldosterone ... ost steroidogenic reactions are catalysed by enzymes of the [[cytochrome]] P450 family. They are located within the mitochondria and require adrenodoxin a ...17 KB (2332 words) - 11:48, 19 February 2009
- 20-Hydroxyecdysone ... n insects that are derived from enzymatic modification of cholesterol by [[p450]] enzymes. This occurs by a mechanism similar to [[steroid synthesis]] in ...10 KB (1393 words) - 05:02, 3 November 2008
- Serotonin ... yptamine, which is then [[Hydroxylation|hydroxylated]] by the [[cytochrome P450 monooxygenase]], [[tryptamine 5-hydroxylase]], yielding serotonin.<ref nam ...38 KB (5178 words) - 12:28, 19 February 2009
- 17-alpha-Hydroxyprogesterone ... from [[progesterone]] via [[17-hydroxylase]], a [[Cytochrome P450 oxidase|P450c17 enzyme]], or from [[17-hydroxypregnenolone]] via 3β-hydroxysteroid deh ...6 KB (817 words) - 10:07, 19 February 2009
- 17-Hydroxypregnenolone ... is performed by the [[mitochondria]]l [[cytochrome P450 oxidase|cytochrome P450 enzyme]] 17α-hydroxylase ([[CYP17A1]]) that is present in the [[adrenal] ...5 KB (643 words) - 11:24, 19 February 2009
- Ecdysterone ... n insects that are derived from enzymatic modification of cholesterol by [[p450]] enzymes. This occurs by a mechanism similar to [[steroid synthesis]] in ...10 KB (1500 words) - 04:09, 24 February 2009
