PolysacDB 125 Kda antigen 2394
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
125 Kda antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Streptococcus mutans OMZ175 (serotype f)
[edit] Basic Structure
N/A
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
Cell wall extracted antigens
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab LOSM2
[edit] Antibody type and class
IgM
[edit] Assay System
Western blotting and immunoprecipitation techniques, enzyme-linked immunosorbent assay (ELISA), and competitive ELISA
[edit] Cross-reactivity
Monoclonal antibody LOSM1 showed a quite identical reactivity with WEA from S. mutans serotypes f and b, reduced activity against WEA from serotypes c, e, and a, and weak binding to serotypes d and g
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
Using this monoclonal antibody, it has been demonstrated that cross-reactivity and conservation of the specific epitopes among the various S. mutans serotypes. These Mab should be useful in studying the streptococcal surface moities
