Rv2093c
From DrugPedia: A Wikipedia for Drug discovery
| Rv2093c
| |
| Name | |
| Sec-independent protein translocase transmembrane protein TatC | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | C14H12ClN3O3S [1] |
| Mol. wt. | 33824 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 9.4075 |
Contents |
[edit] General
INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT.
Rv2093c, (MT2154, MTCY49.33c), len: 308 aa. Probable tatC, transmembrane protein, component of twin-arginine translocation protein export system (see citation below), equivalent to U00017|U00017_1 from Mycobacterium leprae (317 aa), FASTA scores: opt: 1722, E(): 0, (84.5% identity in 310 aa overlap). Similarity to others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 Sec-independent protein translocase protein from E. coli strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344, E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO THE TATC FAMILY.
Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Essential gene, determined by allelic exchange experiments (See Saint-Joanis et al., 2006). mutants available at TARGET website
[edit] Protein Sequence
>Rv2093c, TB.seq 2352104:2353027 MW:33824 VRAAGLLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAAILVTTIFGFVWYSHSIFGLDSLGEWLRHPYCALPQS ARADISADGECRLLATAPFDQFMLRLKVGMAAGIVLACPVWFYQLWAFITPGLYQRERRFAVAFVIPAAVLFVAGAVLAY LVLSKALGFLLTVGSDVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNLAGLLTYERLKSWRRGLIFAMFVFAAIF TPGSDPFSMTALGAALTVLLELAIQIARVHDKRKAKREAAIPDDEASVIDPPSPVPAPSVIGSHDDVT
[edit] Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|Q96C10.1 | 29 | 42 | 126 | 0.73 |
| sp|P23109.1 | 29 | 42 | 77 | 1.9 |
| sp|A8MVW0.1 | 36 | 50 | 63 | 4.8 |
| sp|Q92766.3 | 52 | 66 | 21 | 4.8 |
| sp|Q8WXG6.2 | 32 | 50 | 52 | 5.5 |
[edit] Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
[edit] Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
[edit] Subcellular Location
Link to TBpred
Integral Membrane
[edit] Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
[edit] B cell Epitopes
[edit] BCEpred Analysis
Link to Bcepred
Result Predicited by [2]
[edit] ABCpred Analysis
Link to ABCpred
Result Predicited by [3]
[edit] IEDB Analysis
Link to IEDB
Result Predicited by [4]
[edit] MHC Class-I Binder
[edit] nHLAPred Analysis
Link to nHLApred
Result Predicited by [5]
[edit] IEDB Analysis
Link to IEDB
Result Predicted by [6]
[edit] MHC Class-II Binder
[edit] Propred Analysis
Link to Propred
Result Predicted by [7]
[edit] NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by [8]
[edit] External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
