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'''Dopamine'''
Pubchem(681)

One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.


'''Therapeutic Indications'''
* Hypotension
* Parkinson Disease

'''Therapeutic Uses'''
* cns agent
* cardiovascular agent

'''KEGG Pathway'''(C03758,D07870)
*Tyrosine metabolism
*Indole and ipecac alkaloid biosynthesis
*Alkaloid biosynthesis I
*Neuroactive ligand-receptor interaction
*Gap junction
*Parkinson's disease

'''Activity''' 	Antihypotensive,Cardiac stimulant, cardiotonic
{| border="1;width:100%; height:200px;style=text-align:center"
|+'''List of PDB files having Dopamine as a Ligand:'''
|-
! style="background:brown; color:white" |MMDB ID
! style="background:brown; color:white" |PDB ID 
! style="background:brown; color:white" |Reference
|-
|34790
|2A3R
|Lu JH, Li HT, Liu MC, Zhang JP, Li M, An XM, Chang WRCrystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphateBiochem. Biophys. Res. Commun. v335, p.417-423
|-
|58509
|5PAH
|Erlandsen H, Flatmark T, Stevens RC, Hough ECrystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolutionBiochemistry v37, p.15638-15646
|-
|65041
|2QMZ
|Fu Y, Buryanovskyy L, Zhang Z, 2007/7/17 
|-
|65825
|2VQ5
|Ilari A, Franceschini S, Bonamore A, Boffi A, 2008/3/11 
|-
|}

{| border="1;width:100%; height:200px;style=text-align:center"
|+'''Physiochemical properties of Dopamine:'''
|-
! style="background:brown; color:white" |Physical Property
! style="background:brown; color:white" |Value
! style="background:brown; color:white" |Units 
! style="background:brown; color:white" |Temp (deg C)
! style="background:brown; color:white" |Source
|-
|Melting Point 	
|128 	
|deg C 
|	  	
|EXP
|-
|pKa Dissociation Constant 	
|8.93 	
|(none) 
|	  	
|EXP
|-
|log P (octanol-water) 	
|0.98 	
|(none) 	
|  	
|EXP
|-
|Water Solubility 	
|1.00E+06 	
|mg/L 	
|25 	
|EST
|-
|Vapor Pressure 	
|2.57E-05 	
|mm Hg 	
|25 	
|EST
|-
|Henry's Law Constant 	
|8.79E-15 	
|atm-m3/mole 	
|25 	
|EST
|-
|Atmospheric OH Rate Constant 	
|9.01E-11 	
|cm3/molecule-sec 	
|25 	
|EST
|-
|}
{| border="1;width:100%; height:200px;style=text-align:center"
|+'''Toxicity:'''
|-
! style="background:brown; color:white" |Organism 
! style="background:brown; color:white" |Test Type  
! style="background:brown; color:white" |Route  
! style="background:brown; color:white" |Reported Dose (Normalized Dose)
! style="background:brown; color:white" |Effect
! style="background:brown; color:white" |Source
|-
|mammal (species unspecified) 	
|LD50 	
|unreported 	
|1120mg/kg (1120mg/kg) 	  
|	
|Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 42, 1990.
|-
|mouse 	
|LD50 	
|intracervical 	
|74mg/kg (74mg/kg) 	
|BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) 	
|Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980.
|-
|mouse 	
|LD50 	
|intraperitoneal 	
|950mg/kg (950mg/kg) 	
|SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: HEMORRHAGE 	
|Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974.
|-
|mouse 	
|LD50 	
|intravenous 	
|59mg/kg (59mg/kg) 	
|SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: HEMORRHAGE 	
|Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 835, 1974.
|-
|rat 	
|LD50 	
|intraperitoneal 	
|163mg/kg (163mg/kg) 	
|LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" 	
|Toxicology and Applied Pharmacology. Vol. 88, Pg. 433, 1987.
|-
|}