Rv0014c
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
(New page: {{immunebox | Name =<b> Serine/threonine-protein kinase pknB </b> |image= | width=250 |image2= |Swiss Prot = P0A5S4 | Genbank = 887072 | PDB = 3F61,3F69,2FUM,...) |
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|Swiss Prot = P0A5S4 | |Swiss Prot = P0A5S4 | ||
| Genbank = 887072 | | Genbank = 887072 | ||
| - | | PDB = 3F61 | + | | PDB = 3F61 |
| DrugBank = | | DrugBank = | ||
| chemical_formula = C21H33NO2 [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=887072&loc=ec_rcs] | | chemical_formula = C21H33NO2 [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=887072&loc=ec_rcs] | ||
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=General= | =General= | ||
INVOLVED IN SIGNAL TRANSDUCTION (VIA PHOSPHORYLATION). THOUGHT TO REGULATE CELL DIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDE SUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]. | INVOLVED IN SIGNAL TRANSDUCTION (VIA PHOSPHORYLATION). THOUGHT TO REGULATE CELL DIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDE SUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN]. | ||
| + | |||
| + | Other PDBID: 3F69, 2FUM, 1MRU, 1O6Y | ||
==Protein Sequence== | ==Protein Sequence== | ||
| - | |||
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEA | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEA | ||
ETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA | ETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA | ||
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TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQ | TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQ | ||
FVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ | FVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ | ||
| - | |||
| - | |||
=Human Homologue Blast Result= | =Human Homologue Blast Result= | ||
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<td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr> | <td>subject ids</td><td>% identity</td><td>% positives</td><td>alignment length</td><td> evalue</td></tr> | ||
| - | </table> | + | <tr><td>sp|P51957.2</td><td> 30</td><td> 47</td><td> 285</td><td> 2e-26</td></tr> |
| + | |||
| + | <tr><td>sp|P51956.2</td><td> 32</td><td> 50</td><td> 256</td><td> 2e-26</td></tr> | ||
| + | |||
| + | <tr><td>sp|Q96L34.1</td><td> 27</td><td> 47</td><td> 273</td><td> 7e-26</td></tr> | ||
| + | |||
| + | <tr><td>sp|Q7KZI7.2</td><td> 29</td><td> 45</td><td> 295</td><td> 1e-25</td></tr> | ||
| + | |||
| + | <tr><td>sp|Q8IWQ3.3</td><td> 32</td><td> 52</td><td> 212</td><td> 2e-25</td></tr></table> | ||
=Alergen Protein= | =Alergen Protein= | ||
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=Subcellular Location= | =Subcellular Location= | ||
Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br> | Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br> | ||
| - | + | Cytoplasmic | |
=Antigens= | =Antigens= | ||
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Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred] | Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred] | ||
<br> | <br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/R14.pdf]<br> |
====ABCpred Analysis==== | ====ABCpred Analysis==== | ||
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br> | Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/R141.pdf]<br> |
====IEDB Analysis==== | ====IEDB Analysis==== | ||
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br> | Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/R142.pdf]<br> |
=MHC Class-I Binder= | =MHC Class-I Binder= | ||
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Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred] | Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred] | ||
<br> | <br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/R143.pdf]<br> |
==IEDB Analysis== | ==IEDB Analysis== | ||
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br> | Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br> | ||
| - | Result Predicted by | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/R144.pdf]<br> |
=MHC Class-II Binder= | =MHC Class-II Binder= | ||
==Propred Analysis== | ==Propred Analysis== | ||
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br> | Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br> | ||
| - | Result Predicted by | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/R145.pdf]<br> |
==NetMHC-II Analysis== | ==NetMHC-II Analysis== | ||
Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br> | Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br> | ||
| - | Result Predicted by | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/R146.pdf]<br> |
=External Links= | =External Links= | ||
Current revision
| Rv0014c
| |
| Name | |
| Serine/threonine-protein kinase pknB | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | |
| Chemical data | |
| Formula | C21H33NO2 [1] |
| Mol. wt. | 66511 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 5.08 |
Contents |
[edit] General
INVOLVED IN SIGNAL TRANSDUCTION (VIA PHOSPHORYLATION). THOUGHT TO REGULATE CELL DIVISION/DIFFERENTIATION. CAN PHOSPHORYLATE THE PEPTIDE SUBSTRATE MYELIN BASIC PROTEIN (MBP) [CATALYTIC ACTIVITY: ATP + A PROTEIN = ADP + A PHOSPHOPROTEIN].
Other PDBID: 3F69, 2FUM, 1MRU, 1O6Y
[edit] Protein Sequence
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEA ETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIA RAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSAAGNLSGPRTDPLPRQDLDDT DRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDVQVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVI GTDPAANTSVSAGDEITVNVSTGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPPAGTTVPVDSVIELQVSKGNQ FVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQHNRVVYQNPPAGTGVNRDGIITLRFGQ
[edit] Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|P51957.2 | 30 | 47 | 285 | 2e-26 |
| sp|P51956.2 | 32 | 50 | 256 | 2e-26 |
| sp|Q96L34.1 | 27 | 47 | 273 | 7e-26 |
| sp|Q7KZI7.2 | 29 | 45 | 295 | 1e-25 |
| sp|Q8IWQ3.3 | 32 | 52 | 212 | 2e-25 |
[edit] Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
[edit] Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
[edit] Subcellular Location
Link to TBpred
Cytoplasmic
[edit] Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
[edit] B cell Epitopes
[edit] BCEpred Analysis
Link to Bcepred
Result Predicited by [2]
[edit] ABCpred Analysis
Link to ABCpred
Result Predicited by [3]
[edit] IEDB Analysis
Link to IEDB
Result Predicited by [4]
[edit] MHC Class-I Binder
[edit] nHLAPred Analysis
Link to nHLApred
Result Predicited by [5]
[edit] IEDB Analysis
Link to IEDB
Result Predicted by [6]
[edit] MHC Class-II Binder
[edit] Propred Analysis
Link to Propred
Result Predicted by [7]
[edit] NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by [8]
[edit] External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
