Rv0189c
From DrugPedia: A Wikipedia for Drug discovery
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Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred] | Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred] | ||
<br> | <br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/Rv018.pdf]<br> |
====ABCpred Analysis==== | ====ABCpred Analysis==== | ||
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br> | Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/Rv0181.pdf]<br> |
====IEDB Analysis==== | ====IEDB Analysis==== | ||
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br> | Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/Rv0182.pdf]<br> |
=MHC Class-I Binder= | =MHC Class-I Binder= | ||
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Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred] | Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred] | ||
<br> | <br> | ||
| - | Result Predicited by | + | Result Predicited by [http://crdd.osdd.net/drugpedia/images/Rv0183.pdf]<br> |
==IEDB Analysis== | ==IEDB Analysis== | ||
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br> | Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br> | ||
| - | Result Predicted by [http://crdd.osdd.net/drugpedia/images/ | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv0184.txt.pdf]<br> |
=MHC Class-II Binder= | =MHC Class-II Binder= | ||
==Propred Analysis== | ==Propred Analysis== | ||
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br> | Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br> | ||
| - | Result Predicted by | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv0185.pdf]<br> |
==NetMHC-II Analysis== | ==NetMHC-II Analysis== | ||
Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br> | Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br> | ||
| - | Result Predicted by | + | Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv186.txt]<br> |
=External Links= | =External Links= | ||
Revision as of 11:07, 14 February 2010
| Rv0189c
| |
| Name | |
| DIHYDROXY-ACID DEHYDRATASE (DAD) (ILVD) | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | C13H13N3OS [1] |
| Mol. wt. | 59353 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 4.8 |
Contents |
General
INVOLVED IN VALINE AND ISOLEUCINE BIOSYNTHESIS (AT THE FOURTH STEP) [CATALYTIC ACTIVITY: 2,3-DIHYDROXY-3-METHYLBUTANOATE = 3-METHYL-2- OXOBUTANOATE + H(2)O]. essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website
Protein Sequence
>Rv0189c, TB.seq 219997:221721 MW:59353 MPQTTDEAASVSTVADIKPRSRDVTDGLEKAAARGMLRAVGMDDEDFAKPQIGVASSWNEITPCNLSLDRLANAVKEGVF SAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYA GSILPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAP PATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDFSRIGSGV PHLADVKPFGRHVMSDVDHIGGVPVVMKALLDAGLLHGDCLTVTGHTMAENLAAITPPDPDGKVLRALANPIHPSGGITI LHGSLAPEGAVVKTAGFDSDVFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGK DVLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALLRNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSK YVKLVSSAAVGAVCG
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|P52701.2 | 26 | 47 | 53 | 3.4 |
| sp|P08034.1 | 24 | 44 | 93 | 3.7 |
| sp|Q9HBR0.2 | 41 | 56 | 39 | 3.7 |
| sp|Q9Y2L5.1 | 19 | 36 | 205 | 6.1 |
| sp|P46926.1 | 30 | 39 | 113 | 6.7 |
Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
Subcellular Location
Link to TBpred
Cytoplasmic
Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
B cell Epitopes
BCEpred Analysis
Link to Bcepred
Result Predicited by [2]
ABCpred Analysis
Link to ABCpred
Result Predicited by [3]
IEDB Analysis
Link to IEDB
Result Predicited by [4]
MHC Class-I Binder
nHLAPred Analysis
Link to nHLApred
Result Predicited by [5]
IEDB Analysis
Link to IEDB
Result Predicted by [6]
MHC Class-II Binder
Propred Analysis
Link to Propred
Result Predicted by [7]
NetMHC-II Analysis
Link to NetMHC-II
Result Predicted by [8]
External Links
- Database of Mycobacterium tuberculosis genome sequences and related information.
