PolysacDB Glucurunoxylomannan 1013

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1 Carbohydrate Name
2 Carbohydrate Class
3 Source Microbe
4 Basic Structure
5 Proposed functions
6 Antigenic Nature used to produce antibodies
7 Carrier Name
8 Conjugation Method
9 Antibodies
10 Antibody type and class
11 Assay System
12 Cross-reactivity
13 Proposed epitopes
14 Proposed Utility
15 Weblink
16 External Links

[edit] Carbohydrate Name

Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans serotype A

[edit] Basic Structure

The GXM backbone consists of a linear α(1-->3)-linked mannan substituted at 2-O positions by single residues of either xylose or glucuronic acid

[edit] Proposed functions

Antiphagocytic ; an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Pure Capsular polysaccharide

[edit] Carrier Name

N/A

[edit] Conjugation Method

N/A

[edit] Antibodies

Mab E1

[edit] Antibody type and class

IgG1

[edit] Assay System

Agglutination with C. neoformans serotype A cells, Radial immunodiffusion, Indirect Immunofluorescence,, ELISA, Competitive binding assays

[edit] Cross-reactivity

This antibody was highly specific to serotype A, low levels of cross reactivity to serotypes B and D. Among the other yeasts tested, a cross-reaction was only detected with Trichosporon beigelii.

[edit] Proposed epitopes

N\A

[edit] Proposed Utility

could be useful for fundamental studies on the glucuronoxylomannan structure, as well as for clinical applications such as serotyping and possibly the serological diagnosis of cryptococcosis