PolysacDB 2472
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
Excretory-secretory antigen [ES]
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Toxocara canis
[edit] Basic Structure
Excretory-secretory (ES) antigens of this species are composed of a restricted range of components, with overlapping but not identical profiles. The ES antigens range in m.w. from 32,000 (32 KDa) to 400 KDa and include at least one allergenic component. They are each glycoproteins, containing in all 40% by weight of carbohydrate, and differential lectin binding and protease sensitivity indicate that the major components are discrete parasite antigens rather than degradation products of common derivation
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
T. canis larvae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Tcn-1
[edit] Antibody type and class
IgG1
[edit] Assay System
ELISA, immunoblotting, immunofluorescence, Immunoradiometric assay and inhibition assay
[edit] Cross-reactivity
This Mab cross-reacted and showed positive reactions to surface and ES antigens of T. cati, but did not react with surface-labeled antigens of the nematodes T.spiralis, Heligmososmoides polygyrus. or B. pahangi
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab has been used to determine which epitopes are exposed and which are inaccessible to the parasite surface. These probes indicate that a major parasite antigen is not expressed, or exposed, on the larval surface on emergence from the infective ovum. but subsequently takes its place as the most prominent surface antigen
