Rv3634c

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(New page: {{immunebox | Name =<b> molecular chaperone DnaK </b> |image= | width=250 |image2= |Swiss Prot = Q6MWV3 | Genbank = 885765 | PDB = 3FIG, 1SR9 | DrugBank ...)
Current revision (13:41, 24 February 2010) (edit) (undo)
 
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{{immunebox
{{immunebox
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| Name        =<b>  molecular chaperone DnaK    </b>
+
| Name        =<b> galE1   </b>
|image=
|image=
| width=250
| width=250
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|Swiss Prot =  Q6MWV3
|Swiss Prot =  Q6MWV3
| Genbank          = 885765
| Genbank          = 885765
-
| PDB        = 3FIG, 1SR9
+
| PDB        =
| DrugBank          =
| DrugBank          =
-
| chemical_formula  = C18H21NO3   [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=885946&loc=ec_rcs]
+
| chemical_formula  = C10H12ClNO2   [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pccompound&term=885765]
| molecular_weight  = 33550  Da
| molecular_weight  = 33550  Da
| solubility        =  
| solubility        =  
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=Subcellular Location=
=Subcellular Location=
Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
Link to [http://www.imtech.res.in/raghava/tbpred/ TBpred]<br>
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Integral Membrane
+
Cytoplasmic
=Antigens=
=Antigens=
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Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]   
Link to [http://www.imtech.res.in/raghava/bcepred/bcepred_submission.html Bcepred]   
<br>
<br>
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Result Predicited by   
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/Rv3634.pdf]<br>
====ABCpred Analysis====
====ABCpred Analysis====
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
Link to [http://www.imtech.res.in/raghava/abcpred/ABC_submission.html ABCpred]<br>
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Result Predicited by   
+
Result Predicited by  [http://crdd.osdd.net/drugpedia/images/Rv36341.pdf]<br>
====IEDB Analysis====
====IEDB Analysis====
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
Link to [http://tools.immuneepitope.org/tools/bcell/iedb_input IEDB]<br>
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Result Predicited by   
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/Rv36342.pdf]<br>
=MHC Class-I Binder=
=MHC Class-I Binder=
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Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
Link to [http://www.imtech.res.in/raghava/nhlapred/comp.html nHLApred]
<br>  
<br>  
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Result Predicited by  [http://crdd.osdd.net/drugpedia/images/Nhlapred_rv2753c.pdf nHLApred]<br>
+
Result Predicited by  [http://crdd.osdd.net/drugpedia/images/Rv36343.pdf]<br>
==IEDB Analysis==
==IEDB Analysis==
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
Link to [http://tools.immuneepitope.org/analyze/html/mhc_processing.html IEDB] <br>
-
Result Predicted by [http://crdd.osdd.net/drugpedia/images/IEDB_mhc_rv2753c.pdf IEDB]
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Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv36344.txt]<br>
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=MHC Class-II Binder=
=MHC Class-II Binder=
==Propred Analysis==
==Propred Analysis==
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
Link to [http://www.imtech.res.in/raghava/propred/ Propred]<br>
-
Result Predicted by
+
Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv36345.pdf]<br>
==NetMHC-II Analysis==
==NetMHC-II Analysis==
Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>
Link to [http://www.cbs.dtu.dk/services/NetMHCII/ NetMHC-II]<br>
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Result Predicted by  
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Result Predicted by [http://crdd.osdd.net/drugpedia/images/Rv36346.txt]<br>
=External Links=
=External Links=

Current revision

Rv3634c
Name
galE1
Identifiers
Swiss Prot Q6MWV3
Genbank 885765
PDB  ?
Chemical data
Formula C10H12ClNO2 [1]
Mol. wt. 33550 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point 6.2

Contents

[edit] General

POSSIBLY INVOLVED IN SYNTHESIS OF A-BAND COMMON ANTIGEN LIPOPOLYSACCHARIDE. FIRST OF THE THREE STEPS IN THE BIOSYNTHESIS OF GDP-FUCOSE FROM GDP-MANNOSE [CATALYTIC ACTIVITY: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O].

Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

[edit] Protein Sequence

>Rv3634c, TB.seq 4072667:4073608 MW:33550 VRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAHVFVEADIVTADLHAILEQHRPEVVFHLAAQ IDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTF RHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNI GTGKETSDRQLHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDIGLAERVLGWRPQIELADGVRRTVEYFRHKHTD





[edit] Human Homologue Blast Result

subject ids% identity% positivesalignment length evalue
sp|O95455.1 29 48 318 2e-34
sp|Q8NBZ7.1 29 49 316 5e-34
sp|Q14376.2 28 41 328 3e-17
sp|O60547.1 26 42 342 8e-17
sp|Q15738.2 24 40 356 1e-13

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cytoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]


[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

  • Database of Mycobacterium tuberculosis genome sequences and related information.
Retrieved from "http://140949.jxltd.asia/drugpedia/index.php/Rv3634c"