PolysacDB CA antigen 1127

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:03, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:45, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

CA antigen

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Aspergillus fumigatus 2085

[edit] Basic Structure

Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides

[edit] Proposed functions

The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions

[edit] Antigenic Nature used to produce antibodies

Cell walls of A. fumigatus 2085

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab SC1

[edit] Antibody type and class

IgM

[edit] Assay System

Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays

[edit] Cross-reactivity

MAb SC1 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes

[edit] Proposed epitopes

Galactomannan residues seemed to be the part of immunodominant region

[edit] Proposed Utility

These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database