Rv2155c

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(New page: {{immunebox | Name =<b>UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase </b> |image= | width=250 |image2= |Swiss Prot = O06222 | Genbank = 888000 | PDB ...)
Current revision (19:31, 13 April 2010) (edit) (undo)
(New page: {{immunebox | Name =<b>UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase </b> |image= | width=250 |image2= |Swiss Prot = O06222 | Genbank = 888000 | PDB ...)
 

Current revision

Rv2155c
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Identifiers
Swiss Prot O06222
Genbank 888000
PDB  ?
Chemical data
Formula C11H12INO2 [1]
Mol. wt. 49314 Da
Pharmacokinetic data
Bioavailability  ?
Solubility  ?
Isoelectric-Point 5.2468

Contents

[edit] General

INVOLVED IN CELL WALL FORMATION; PEPTIDOGLYCAN BIOSYNTHESIS.

Rv2155c, (MTCY270.13), len: 486 aa. Probable murD, UDP-N-acetylmuramoylalanine-D-glutamate ligase (see citation below), similar to others e.g. MURD_BACSU|Q03522 (451 aa), FASTA scores: opt: 534, E(): 2.7e-25, (28.8% identity in 483 aa overlap); etc. Contains PS01011 Folylpolyglutamate synthase signature 1.

Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

[edit] Protein Sequence

>Rv2155c, TB.seq 2414935:2416392 MW:49314 VLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDAVQQITGYALVVASPGFSPAT PLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPA ELLAVELSSFQLHWAPSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFR LGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAV ADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQ VVAGEDTGMPATVEVPVACVLDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATA VRAVIR





[edit] Human Homologue Blast Result

subject ids% identity% positivesalignment length evalue
sp|P35606.2 29 46 71 0.12
sp|Q96DW6.1 34 51 490.71
sp|Q9Y5I0.1 23 45 84 1



[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cytoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]


[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

  • Database of Mycobacterium tuberculosis genome sequences and related information.