PolysacDB 2476
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[edit] Carbohydrate Name
Excretory-secretory antigen [ES]
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Toxocara canis
[edit] Basic Structure
Excretory-secretory (ES) antigens of this species are composed of a restricted range of components, with overlapping but not identical profiles. The ES antigens range in m.w. from 32,000 (32 KDa) to 400 KDa and include at least one allergenic component. They are each glycoproteins, containing in all 40% by weight of carbohydrate, and differential lectin binding and protease sensitivity indicate that the major components are discrete parasite antigens rather than degradation products of common derivation
[edit] Proposed functions
N/A
[edit] Antigenic Nature used to produce antibodies
T. canis larvae
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Tcn-7
[edit] Antibody type and class
IgM
[edit] Assay System
ELISA, immunoblotting, immunofluorescence, Immunoradiometric assay and inhibition assay
[edit] Cross-reactivity
This Mab cross-reacted and showed positive reactions to surface and ES antigens of T. cati, but did not react with surface-labeled antigens of the nematodes T.spiralis, Heligmososmoides polygyrus. or B. pahangi
[edit] Proposed epitopes
N/A
[edit] Proposed Utility
This Mab can be used for elucidating the biological functions of the secreted glycoproteins in an attempt to define the molecular parameters of toxocaral parasitism and pathogenesis
