5-hydroxytryptamine 2 receptor
From DrugPedia: A Wikipedia for Drug discovery
m (1 revision) |
|||
| Line 1: | Line 1: | ||
| + | ==Description== | ||
| + | '''5-HT2 receptors''' are a family of [[5-HT receptors]], with the following members: | ||
| + | *[[5-HT2A receptor|5-HT<sub>2A</sub> receptor]]s | ||
| + | *[[5-HT2B receptor|5-HT<sub>2B</sub> receptor]]s | ||
| + | *[[5-HT2C receptor|5-HT<sub>2C</sub> receptor]]s | ||
| - | ==Source Organism== | + | Multiple receptor subtypes of [[serotonin]] (5-HT) [[neurotransmitter]]s with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. [[Cardiovascular]] effects include contraction of [[blood vessels]] and shape changes in [[platelets]]; [[central nervous system]] effects include neuronal [[sensitization]] to tactile stimuli and mediation of [[hallucinogenic]] effects of [[phenylisopropylamine]] hallucinogens. <ref name="entrez"> [supplied by OMIM] {{cite web | title = Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3357| accessdate = }}</ref> |
| + | |||
| + | ===Source Organism=== | ||
Aplysia californica (California sea hare). | Aplysia californica (California sea hare). | ||
| - | ==Taxomomy== | + | ===Taxomomy=== |
Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda;Apogastropoda; Heterobranchia; Euthyneura; Opisthobranchia; Anaspidea;Aplysioidea; Aplysiidae; Aplysia. | Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda;Apogastropoda; Heterobranchia; Euthyneura; Opisthobranchia; Anaspidea;Aplysioidea; Aplysiidae; Aplysia. | ||
| - | ==Subcellular Localization== | + | ===Subcellular Localization=== |
Cell membrane; multi-pass membrane protein. | Cell membrane; multi-pass membrane protein. | ||
| - | ==Developmental Stage== | + | ===Developmental Stage=== |
| - | ==Similarity== | + | ===Similarity=== |
Belongs to the G-protein coupled receptor 1 family. | Belongs to the G-protein coupled receptor 1 family. | ||
==Post translational Modification== | ==Post translational Modification== | ||
| Line 16: | Line 23: | ||
[[Categories:Receptors]] | [[Categories:Receptors]] | ||
| + | {{Wrongtitle|title=5-HT<sub>2</sub> receptor}} | ||
Revision as of 11:21, 16 February 2009
Contents |
Description
5-HT2 receptors are a family of 5-HT receptors, with the following members:
Multiple receptor subtypes of serotonin (5-HT) neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens. <ref name="entrez"> [supplied by OMIM] Template:Cite web</ref>
Source Organism
Aplysia californica (California sea hare).
Taxomomy
Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda;Apogastropoda; Heterobranchia; Euthyneura; Opisthobranchia; Anaspidea;Aplysioidea; Aplysiidae; Aplysia.
Subcellular Localization
Cell membrane; multi-pass membrane protein.
Developmental Stage
Similarity
Belongs to the G-protein coupled receptor 1 family.
Post translational Modification
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin). 5-HT plays important roles in various behavioral and physiological processes in aplysia. These include feeding, locomotion, circadian rhythm, learning and memory, synaptic plasticity, and synaptic growth. This receptor is mediated by G proteins that stimulate phospholipase C.
