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Revision as of 16:32, 6 March 2010

Immunotation of Rv3459c
Name
PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK
Identifiers
Swiss Prot	O06326
Genbank	886959
PDB	2wdh
Chemical data
Formula	[1]
Mol. wt.	14786 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	6.52

General

S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.

Protein Sequence

>Rv3459c, TB.seq 3879272:3879688 MW:14786

MPPAKKGPAT SARKGQKTRR REKKNVPHGA AHIKSTFNNT IVTITDPQGN VIAWASSGHV

       70         80         90        100        110        120 

GFKGSRKSTP FAAQLAAENA ARKAQDHGVR KVDVFVKGPG SGRETAIRSL QAAGLEVGAI

      130 

SDVTPQPHNG VRPPKRRRV