CarboDB Lipoarabinomannan 1036
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 00:00, 15 January 2001
Carbohydrate Name
Lipoarabinomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Mycobacterium leprae
Basic Structure
Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
Proposed functions
T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages
Antigenic Nature used to produce antibodies
whole killed mycobacteria leprae cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab Cs-35
Antibody type and class
IgM
Assay System
Indirect and Competitive ELISA
Cross-reactivity
This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.
Proposed epitopes
β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans
Proposed Utility
These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.
