CarboDB Lipopolysaccharide 1392

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Salmonella minnesota R595

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

acid-treated and lipid A-coated S. minnesota R597

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 1F2

Antibody type and class

IgG1

Assay System

ELISA, immunoblotting and RIA

Cross-reactivity

This antibody cross-reacted with E. coli J5, , S. minnesota R595, but did not cross-react with Staphylococcus aureus, E. Coli O111:B4, K. pneumoniae, S. marcescens and P. Aeruginosa and Staphylococcus faecalis

Proposed epitopes

N/A

Proposed Utility

N/A

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to CarboDB database