CarboDB Tetrasaccharide 2001

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Tetrasaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Streptococcus pneumoniae serotype 6B

[edit] Basic Structure

The structure of the trisaccharide is α-L-Rhap-(1-->4)-D-Rib-ol-(5-->P-->2)-α-D-Galp-(1-->3)-α-D-Glcp-[1-->O(CH2)3NH2]

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Keyhole limpet hemocyanin

[edit] Conjugation Method

The saccharides were coupled via the 3-aminopropyl spacer to carrier protein KLH in a stepwise reaction: the amino-terminal groups of the OS fragment and KLH were activated by S acetylation and Br acetylation, respectively, and coupled via a thioether linkage

[edit] Antibodies

Antisera

[edit] Antibody type and class

N/A

[edit] Assay System

ELISA, phagocytosis assays and protection experiments

[edit] Cross-reactivity

This antisera cross-reacted with capsular polysaccharide of 6A strains

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This antisera could passively protect mice against a 6B and 6A challenge

[edit] Weblink

PubMed Central

[edit] External Links

• Link to CarboDB database