Chemogenomics
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(New page: '''Chemogenomics''' can be defined as the study of genomic responses to chemical compounds. The goal is the rapid identification of novel drugs and drug targets embracing multiple early ph...)
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Revision as of 06:04, 17 September 2008
Chemogenomics can be defined as the study of genomic responses to chemical compounds. The goal is the rapid identification of novel drugs and drug targets embracing multiple early phase drug discovery technologies ranging from target identification and validation, over compound design and chemical synthesis to biological testing and ADME profiling.
Introduction
Chemical biology, chemical genetics, and chemogenomics are recent strategies in drug discovery. Although definitions in the literature are somehow diffuse and inconsistent, a differentiation of the terms will be attempted here: Chemical biology may be defined as the study of biological systems, e.g., whole cells, under the influence of chemical libraries. If a new phenotype is discovered by the action of a certain substance, the next step is the identification of the responsible target. Chemical genetics is the dedicated study of protein function, e.g., signaling chains, under the influence of ligands which bind to certain proteins or interfere with protein–protein interaction; sometimes orthog- onalligand–proteinpairsaregeneratedtoachieveselectivityforacertain protein. Chemogenomics defines, in principle, the screening of the chemi- cal universe, i.e., all possible chemical compounds, against the target universe, i.e., all proteins and other potential drug targets. Whereas this task can never be achieved, due to the almost infinite size of the chemical universe, the systematic screening of libraries of congeneric compounds against members of a target family offers unprecedented chances in the search for compounds with significant target or subtype specificity.
