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Current revision

Rv2093c
Name
Sec-independent protein translocase transmembrane protein TatC
Identifiers
Swiss Prot	P66895
Genbank	888068
PDB	?
Chemical data
Formula	C14H12ClN3O3S [1]
Mol. wt.	33824 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	9.4075

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT.

Rv2093c, (MT2154, MTCY49.33c), len: 308 aa. Probable tatC, transmembrane protein, component of twin-arginine translocation protein export system (see citation below), equivalent to U00017|U00017_1 from Mycobacterium leprae (317 aa), FASTA scores: opt: 1722, E(): 0, (84.5% identity in 310 aa overlap). Similarity to others e.g. P27857|TATC_ECOLI|MTTB|B3839|Z5360|ECS4768 Sec-independent protein translocase protein from E. coli strain K12 and O157:H7 (258 aa), FASTA scores: opt: 344, E(): 6e-16, (32.5% identity in 265 aa overlap). BELONGS TO THE TATC FAMILY.

Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Essential gene, determined by allelic exchange experiments (See Saint-Joanis et al., 2006). mutants available at TARGET website

[edit] Protein Sequence

>Rv2093c, TB.seq 2352104:2353027 MW:33824 VRAAGLLKRLNPRNRRSRVNPDATMSLVDHLTELRTRLLISLAAILVTTIFGFVWYSHSIFGLDSLGEWLRHPYCALPQS ARADISADGECRLLATAPFDQFMLRLKVGMAAGIVLACPVWFYQLWAFITPGLYQRERRFAVAFVIPAAVLFVAGAVLAY LVLSKALGFLLTVGSDVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNLAGLLTYERLKSWRRGLIFAMFVFAAIF TPGSDPFSMTALGAALTVLLELAIQIARVHDKRKAKREAAIPDDEASVIDPPSPVPAPSVIGSHDDVT

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q96C10.1	29	42	126	0.73
sp|P23109.1	29	42	77	1.9
sp|A8MVW0.1	36	50	63	4.8
sp|Q92766.3	52	66	21	4.8
sp|Q8WXG6.2	32	50	52	5.5

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Integral Membrane

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.