PolysacDB Capsular polysaccharide 1004

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:02, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Haemophilus influenzae

Basic Structure

A relatively simple antigen consisting of repeating units of 3-β-D ribose-(1-->1)-D-ribitol-5-phosphate

Proposed functions

An important virulence determinant

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Neisseria meningitidis group B outer membrane protein complex (Hib PS-OMP)

Conjugation Method

The strategy uses a oligopeptide spacer molecule whose parts are derived from both modified Haemophilus influenzae capsular polysaccharide and Neisseria meningitides group B outer membrane complex

Antibodies

Polysera

Antibody type and class

IgG1 and IgG2

Assay System

N\A

Cross-reactivity

N/A

Proposed epitopes

N\A

Proposed Utility

These antibodies exert their protective effect by initiating complement-mediated activities including opsonization and bacterial lysis

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database