PolysacDB Lipoarabinomannan 1011
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:02, 8 April 2010
Carbohydrate Name
Lipoarabinomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Mycobacterium tuberculosis
Basic Structure
Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor
Proposed functions
Reported to suppress T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages. Other reported effects include inhibition of protein kinases, inhibition of the synthesis of mRNA encoding IL-2, IL-5, and granulocyte-macrophage colony stimulating factor (GM-CSF) in human T cells and activation of the complement cascade
Antigenic Nature used to produce antibodies
Heat killed Mycobacterium tuberculosis
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab lam701
Antibody type and class
IgG3
Assay System
Sandwich ELISA
Cross-reactivity
This antibody cross-reacted with cross-reacted to a large number of mycobacterial species such as M. tuberculosis, M. bovis, M leprae, M. phlei and M. avium
Proposed epitopes
N\A
Proposed Utility
These antibodies could be used to detect mycobacterial antigens in sputum
