PolysacDB Capsular polysaccharide 1022

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:02, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Cryptococcus neoformans

Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

Proposed functions

The capsular polysaccharide is an important virulence factor

Antigenic Nature used to produce antibodies

Cryptococci cells

Carrier Name

N/A

Conjugation Method

N/A

Antibodies

Mab 20B5

Antibody type and class

IgM

Assay System

ELISA

Cross-reactivity

This antibody was specific to D serotype and cross-reacted with GH strain

Proposed epitopes

N\A

Proposed Utility

This antibody was shown to bind to cryptococcal capsule

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database