Amrinone
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(New page: '''Amrinone''' (INN) or '''inamrinone''', trade name '''Inocor''', is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. ==Class== Ca...)
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Revision as of 05:57, 24 October 2008
Amrinone (INN) or inamrinone, trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor.
It is used in the treatment of congestive heart failure.
Contents |
Class
Cardiac inotrope.
Actions
Increases cardiac contractility, vasodilator. Acts by inhibiting the breakdown of both cAMP and cGMP
Indications
Short-term management of severe CHF.
Contraindications
Patients with history of hypersensitivity to the drug.
Precautions
May increase myocardial ischemia. Blood pressure, pulse, and EKG should be constantly monitored. Amrinone should only be diluted with normal saline or 1/2 normal saline; no dextrose solutions should be used. Furosemide should not be administered into an IV line delivering Amrinone.
Side effects
Reduction in platelets, nausea and vomiting cardiac arrhythmias.
Routes
IV bolus and infusion as described earlier.
Pediatric dosage
Safety in children has not been established
