PolysacDB 1801

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:09, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

N-propionylated α(2-->8)-linked sialooligosaccharides

Carbohydrate Class

Miscellaneous

Source Microbe

Neisseria meningitidis

Basic Structure

N-propionylated α(2-->8)-linked sialooligosaccharides

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days

Antibodies

Mab 11F3

Antibody type and class

IgG3

Assay System

ELISA, bactericidal assays

Cross-reactivity

N/A

Proposed epitopes

The epitope was located on short internal fragments of the polysaccharide

Proposed Utility

This Mab would help in the elucidation of the capsular polysaccharide structure

Weblink

PubMed Central

External Links

• Link to PolysacDB database