PolysacDB Capsular polysaccharide 1971

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Streptococcus pneumoniae strain 6B

[edit] Basic Structure

The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P-

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Tetanus toxoid

[edit] Conjugation Method

The oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid

[edit] Antibodies

Mab 10H8

[edit] Antibody type and class

IgG1

[edit] Assay System

Enzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay

[edit] Cross-reactivity

This Mab reacted with polysaccharides from 11A, 19F and 23F strain but did not recognize type 6A polysaccharide

[edit] Proposed epitopes

disaccharide rhamnose-(1-->4)-ribitol phosphate residues seemed to be the part of the epitope

[edit] Proposed Utility

N/A

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database