PolysacDB O-polysaccharide 2006

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:11, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Pseudomonas aeruginosa serotype 1

Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The O-polysaccharide consists of the following residues : -4)-α-D-GalpNAcA3Ac6NH2-(1-->4)-α-D-GalpNFoA6NH2-(1-->3)-α-D-QuipNAc-(1-->2)-α-L-Rhap-(1-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

antigen extract from Pseudomonas aeruginosa serotype 1 [PVA-1]

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab ES-P-1S-5

Antibody type and class

IgG1

Assay System

ELISA, passive protection tests

Cross-reactivity

This Mab was specific to PVA-1 antigen

Proposed epitopes

N/A

Proposed Utility

This Mab had invivo protective activity

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database