Ethinyl Estradiol

From DrugPedia: A Wikipedia for Drug discovery

(Difference between revisions)
Jump to: navigation, search
(New page: '''Ethinyl Estradiol''' '''Pubchem(5991)''' A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often...)
Line 7: Line 7:
'''Category'''  Hormone   
'''Category'''  Hormone   
'''Activity''' Estrogen
'''Activity''' Estrogen
-
 
+
{| border="1;width:100%; height:200px;style=text-align:center"
-
Physical Property Value Units Temp (deg C) Source
+
|+'''Table I:'''
-
Melting Point 183 deg C   EXP
+
|-
-
log P (octanol-water) 3.67 (none)   EXP
+
! style="background:brown; color:white" |Physical Property
-
Water Solubility 11.3 mg/L 27 EXP
+
! style="background:brown; color:white" |Value
-
Vapor Pressure 2.67E-09 mm Hg 25 EST
+
! style="background:brown; color:white" |Units  
-
Henry's Law Constant 7.94E-12 atm-m3/mole 25 EST
+
! style="background:brown; color:white" |Temp (deg C)
-
Atmospheric OH Rate Constant 1.25E-10 cm3/molecule-sec 25 EST
+
! style="background:brown; color:white" |Source
-
 
+
|-
 +
|Melting Point
 +
|183
 +
|deg C  
 +
|  
 +
|EXP
 +
|-
 +
|log P (octanol-water)
 +
|3.67
 +
|(none)  
 +
|  
 +
|EXP
 +
|-
 +
|Water Solubility
 +
|11.3
 +
|mg/L
 +
|27
 +
|EXP
 +
|-
 +
|Vapor Pressure
 +
|2.67E-09
 +
|mm Hg
 +
|25
 +
|EST
 +
|-
 +
|Henry's Law Constant
 +
|7.94E-12
 +
|atm-m3/mole
 +
|25
 +
|EST
 +
|-
 +
|Atmospheric OH Rate Constant
 +
|1.25E-10
 +
|cm3/molecule-sec
 +
|25
 +
|EST
 +
|-
 +
|}
Organism  Test Type  Route  Reported Dose (Normalized Dose)  Effect  Source
Organism  Test Type  Route  Reported Dose (Normalized Dose)  Effect  Source
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

Revision as of 08:41, 24 October 2008

Ethinyl Estradiol Pubchem(5991)

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

KEGG PATHWAY(C07534,D00554) Category Hormone Activity Estrogen

Table I:
Physical Property Value Units Temp (deg C) Source
Melting Point 183 deg C EXP
log P (octanol-water) 3.67 (none) EXP
Water Solubility 11.3 mg/L 27 EXP
Vapor Pressure 2.67E-09 mm Hg 25 EST
Henry's Law Constant 7.94E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.25E-10 cm3/molecule-sec 25 EST

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

KIDNEY, URETER, AND BLADDER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. mouse LD50 oral 950mg/kg (950mg/kg) Drugs in Japan Vol. -, Pg. 222, 1995. mouse LD50 subcutaneous > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. rat LD50 intraperitoneal 471mg/kg (471mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

KIDNEY, URETER, AND BLADDER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. rat LD50 oral 960mg/kg (960mg/kg) Drugs in Japan Vol. -, Pg. 222, 1995. rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. women TDLo oral 21mg/kg/21D-I (21mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 1, Pg. 1479, 1973. Link to PubMed

Retrieved from "http://140949.jxltd.asia/drugpedia/index.php/Ethinyl_Estradiol"