Ethinyl Estradiol

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'''KEGG PATHWAY'''(C07534,D00554)
'''KEGG PATHWAY'''(C07534,D00554)
-
'''Category'''  Hormone
+
 
 +
'''Category'''  Hormone
 +
 
'''Activity''' Estrogen
'''Activity''' Estrogen
 +
{| border="1;width:100%; height:200px;style=text-align:center"
{| border="1;width:100%; height:200px;style=text-align:center"
|+'''Table I:'''
|+'''Table I:'''
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|Melting Point
|Melting Point
|183
|183
-
|deg C  
+
|deg C  
-
|  
+
|EXP
|EXP
|-
|-
|log P (octanol-water)
|log P (octanol-water)
|3.67
|3.67
-
|(none)  
+
|(none)  
-
|  
+
|EXP
|EXP
|-
|-
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|-
|-
|}
|}
-
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
+
{| border="1;width:100%; height:200px;style=text-align:center"
-
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
+
|+'''Table I:'''
 +
|-
 +
! style="background:brown; color:white" |Organism  
 +
! style="background:brown; color:white" |Test Type
 +
! style="background:brown; color:white" |Route
 +
! style="background:brown; color:white" |Reported Dose (Normalized Dose)
 +
! style="background:brown; color:white" |Effect
 +
! style="background:brown; color:white" |Source
 +
|-
 +
|mouse
 +
|LD50
 +
|intraperitoneal
 +
|250mg/kg (250mg/kg)
 +
|BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
BEHAVIORAL: ATAXIA
-
 
+
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
-
KIDNEY, URETER, AND BLADDER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
+
|Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
-
mouse LD50 oral 950mg/kg (950mg/kg)   Drugs in Japan Vol. -, Pg. 222, 1995.
+
|-
-
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
+
|mouse
-
 
+
|LD50
-
BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
+
|oral
-
rat LD50 intraperitoneal 471mg/kg (471mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
+
|950mg/kg (950mg/kg)  
 +
|  
 +
|Drugs in Japan Vol. -, Pg. 222, 1995.
 +
|-
 +
|mouse
 +
|LD50
 +
|subcutaneous
 +
|> 3gm/kg (3000mg/kg)
 +
|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
 +
|BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
 +
|-
 +
|rat
 +
|LD50
 +
|intraperitoneal
 +
|471mg/kg (471mg/kg)
 +
|BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
BEHAVIORAL: ATAXIA
 +
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
 +
|Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
 +
|-
 +
|rat
 +
|LD50
 +
|oral
 +
|960mg/kg (960mg/kg)
 +
| 
 +
|Drugs in Japan Vol. -, Pg. 222, 1995.
 +
|-
 +
|rat
 +
|LD50
 +
|subcutaneous
 +
|> 2gm/kg (2000mg/kg)
 +
|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
-
KIDNEY, URETER, AND BLADDER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
+
BLOOD: HEMORRHAGE
-
rat LD50 oral 960mg/kg (960mg/kg)   Drugs in Japan Vol. -, Pg. 222, 1995.
+
|Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
-
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
+
|-
 +
|women
 +
|TDLo
 +
|oral
 +
|21mg/kg/21D-I (21mg/kg)
 +
|LUNGS, THORAX, OR RESPIRATION: DYSPNEA
-
BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
+
GASTROINTESTINAL: NAUSEA OR VOMITING
-
women TDLo oral 21mg/kg/21D-I (21mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
+
|Lancet. Vol. 1, Pg. 1479, 1973.
-
 
+
|-
-
GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 1, Pg. 1479, 1973.
+
|}
-
Link to PubMed
+

Revision as of 08:50, 24 October 2008

Ethinyl Estradiol Pubchem(5991)

A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

KEGG PATHWAY(C07534,D00554)

Category Hormone

Activity Estrogen

Table I:
Physical Property Value Units Temp (deg C) Source
Melting Point 183 deg C EXP
log P (octanol-water) 3.67 (none) EXP
Water Solubility 11.3 mg/L 27 EXP
Vapor Pressure 2.67E-09 mm Hg 25 EST
Henry's Law Constant 7.94E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.25E-10 cm3/molecule-sec 25 EST
Table I:
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES

Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
mouse LD50 oral 950mg/kg (950mg/kg) Drugs in Japan Vol. -, Pg. 222, 1995.
mouse LD50 subcutaneous > 3gm/kg (3000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
rat LD50 intraperitoneal 471mg/kg (471mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES

Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
rat LD50 oral 960mg/kg (960mg/kg) Drugs in Japan Vol. -, Pg. 222, 1995.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BLOOD: HEMORRHAGE

Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990.
women TDLo oral 21mg/kg/21D-I (21mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING

Lancet. Vol. 1, Pg. 1479, 1973.
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