PolysacDB Lipopolysaccharide 2324
From DrugPedia: A Wikipedia for Drug discovery
(Difference between revisions)
Revision as of 06:13, 8 April 2010
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Shigella flexneri [polyvalent S. flexneri 2a/3a vaccine (CVD 1207/CVD 1211)]
Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Heat killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Antisera
Antibody type and class
IgG
Assay System
ELISA
Cross-reactivity
This antisera strongly cross-reacted with S. flexneri LPS of serotypes 1a and 1b
Proposed epitopes
N/A
Proposed Utility
N/A
