PolysacDB Glycoprotein GP72 2487

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Current revision (05:53, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glycoprotein GP72

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Trypanosoma cruzi Z2 Esmeraldo/3

[edit] Basic Structure

GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes

[edit] Proposed functions

GP72 may regulate T. cruzi morphogenesis in the insect vector

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab WIC 29.26

[edit] Antibody type and class

IgG2a

[edit] Assay System

ELISA, immunoblotiing, indirect immunofluorescence

[edit] Cross-reactivity

This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1. WIC 29.26 bound to only 2 of the 4 Trypanozome cruzi strains and 23 of the 50 clones tested

[edit] Proposed epitopes

WIC 29.26 binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose

[edit] Proposed Utility

Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database