Colchicine

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Revision as of 05:44, 24 October 2008 (edit) Bharat (Talk | contribs) (New page: Pronouncation: (KOHL-chih-seen) Class: Agent for gout Trade Names: Colchicine - Tablets 0.6 mg ==Pharmacology== Inhibits inflammation and reduces pain and swelling associated with gou...) ← Previous diff		Revision as of 00:00, 15 January 2001 (edit) (undo) Special:Contributions/ (Talk) m Next diff →
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-	Pronouncation: (KOHL-chih-seen)	+	<table align='right' border=1><tr><td><jmol><jmolApplet><size>200</size><script>spin on;color atoms amino;</script><uploadedFileContents>1385.SDF</uploadedFileContents><color>black</color></jmolApplet></jmol></td></tr></table>
		+	[http://crdd.osdd.net/raghava/biadb/str.php?id=1385&show=SHOW-3D Show 3-D Structure]
-	Class: Agent for gout	+	[http://crdd.osdd.net/raghava/biadb/str.php?id=1385&show=SHOW-2D Show 2-D Structure]
-	Trade Names:	+	{{Drugbox
		+	| IUPAC_name        =4-(dipropylsulfamoyl)benzoic acid;N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl)acetamide
		+	| PubChem          = 24848032
		+	| DrugBank          =
		+	| ChemSpiderID      =
		+	| chemical_formula  =C<sub>3</sub><sub>5</sub>H<sub>4</sub><sub>4</sub>N<sub>2</sub>O<sub>1</sub><sub>0</sub>S
		+	| molecular_weight  = 684.79626
		+	| smiles            = N/A
		+	| synonyms          =
		+	| density          =
		+	| melting_point    =
		+	| boiling_point    =
		+	| solubility        =
		+	| bioavailability  =
		+	| protein_bound    =
		+	| metabolism        =
		+	| elimination_half-life =
		+	}}
-	Colchicine - Tablets 0.6 mg	+	==Description==
-	==Pharmacology==
-	Inhibits inflammation and reduces pain and swelling associated with gouty arthritis.	+	==General Properties==
		+	<b>*Molecular Weight</b>
-	==Pharmacokinetics==	+	684.79626
-	'''Absorption'''	+	<b>*Molecular Formula</b>
-	Rapidly absorbed. T max is 0.5 to 2 h.	+	C<sub>3</sub><sub>5</sub>H<sub>4</sub><sub>4</sub>N<sub>2</sub>O<sub>1</sub><sub>0</sub>S
-	'''Distribution'''	+	<b>*IUPAC NAME</b>
-	Large amounts present in bile and intestinal secretions. High concentrations also found in kidney, liver, and spleen. About 50% protein bound. Vd is 1 to 3 L/kg.	+	4-(dipropylsulfamoyl)benzoic acid;N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl)acetamide
-	'''Metabolism'''	+	<b>*Canonical Smiles</b>
-	Undergoes enterohepatic recirculation. Deacetylated primarily by the liver.	+	CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O.CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
-	'''Elimination'''	+	<b>*Isomeric Smiles</b>
-	Plasma t ½ to 10 to 60 min. Excreted via biliary and renal routes; 10% to 20% excreted unchanged in urine.	+	N/A
-	==Indications and Usage==	+	<b>*XLogP</b>
-	Treatment and relief of pain in attacks of acute gouty arthritis; regular prophylaxis between attacks and is often effective in aborting an attack when taken at the first sign of articular discomfort.	+	N/A
-	'''Unlabeled Uses'''	+	<b>*Topological Polar Surface Area</b>
-	Familial Mediterranean fever; hepatic cirrhosis; primary biliary cirrhosis; treatment of Behcet disease; scleroderma; Sweet syndrome	+	158
-	'''Contraindications'''	+	==External Links==
-	Serious GI, renal, hepatic, or cardiac disorders; blood dyscrasias.	+	*[http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24848032 Pubchem]
-	==Dosage and Administration==	+	[http://crdd.osdd.net/raghava/biadb/detail.php?id=1385 Link to BIAdb Database]
-		+
-	'''Acute Gouty Arthritis'''	+
-		+
-	'''Adults'''	+
-		+
-	Initial dose (give at first sign of attack) PO 1.2 mg; then 0.6 every h or 1.2 mg every 2 h until pain is relieved or diarrhea ensues. Total dose is usually 4 to 8 mg. Wait 3 days before initiating a second course of therapy.	+
-		+
-	'''Prophylaxis'''	+
-		+
-	'''Adults'''	+
-		+
-	PO 0.6 mg/day for 3 to 4 days/wk if fewer than 1 attack/yr; if more than 1 attack/yr, 0.6 mg/day. Severe cases may require 1.2 to 1.8 mg/day.	+
-		+
-	'''Surgical Patients'''	+
-		+
-	'''Adults'''	+
-		+
-	PO 0.6 mg 3 times daily for 3 days before and 3 days after surgery.	+
-		+
-	==Storage/Stability==	+
-		+
-	'''Oral'''	+
-		+
-	Store tablets in airtight, light-resistant container.	+
-		+
-	'''Drug Interactions'''	+
-		+
-	None well documented.	+
-		+
-	'''Laboratory Test Interactions'''	+
-		+
-	May cause false-positive results in urine tests for RBCs and hemoglobin.	+
-		+
-	==Adverse Reactions==	+
-		+
-	'''Dermatologic'''	+
-		+
-	Dermatoses; purpura; alopecia.	+
-		+
-	'''GI'''	+
-		+
-	Nausea; vomiting; diarrhea; abdominal pain.	+
-		+
-	'''Hematologic'''	+
-		+
-	Bone marrow depression with aplastic anemia; agranulocytosis, leukopenia or thrombocytopenia (long-term therapy).	+
-		+
-	'''Hepatic'''	+
-		+
-	Elevated alkaline phosphatase and AST.	+
-		+
-	'''Miscellaneous'''	+
-		+
-	Reversible azoospermia; myopathy; peripheral neuritis.	+
-		+
-	==Precautions==	+
-		+
-	'''Monitor'''	+
-		+
-	'''Blood counts'''	+
-		+
-	Check blood counts periodically in patients undergoing long-term therapy.	+
-		+
-	'''Toxicity signs'''	+
-		+
-	Assess for signs of toxicity (eg, abdominal pain, alopecia, nausea, vomiting, diarrhea, myopathy, peripheral neuritis). Notify health care provider immediately if these signs occur.	+
-		+
-	'''Uric acid/Creatinine'''	+
-		+
-	Monitor serum uric acid and creatinine throughout therapy.	+
-		+
-	'''Pregnancy'''	+
-		+
-	Category C (oral).	+
-		+
-	'''Lactation'''	+
-		+
-	Undetermined.	+
-		+
-	'''Children'''	+
-		+
-	Safety and efficacy not established.	+
-		+
-	'''Elderly'''	+
-		+
-	Administer with great caution to elderly and debilitated patients.	+
-		+
-	'''Hepatic Function'''	+
-		+
-	Increased colchicine toxicity may occur.	+
-		+
-	'''GI reactions'''	+
-		+
-	Drug may cause nausea, vomiting, diarrhea, and abdominal pain that may aggravate pre-existing peptic ulcer or spastic colon. Discontinue drug if these symptoms appear.	+
-		+
-	'''Myopathy and neuropathy'''	+
-		+
-	Myoneuropathy may occur and cause weakness in patients with impaired kidney function; serum creatine kinase may be elevated. Usually resolves in 3 to 4 wk after drug withdrawal.	+
-		+
-	'''Vitamin B 12 malabsorption'''	+
-		+
-	Colchicine induces reversible malabsorption of vitamin B 12 with long-term use.	+
-		+
-	==Overdosage==	+
-		+
-	'''Symptoms'''	+
-		+
-	Nausea, severe abdominal pain, vomiting, diarrhea, shock, ST segment elevation, paralysis, respiratory failure, liver damage, renal failure, leukopenia, thrombocytopenia, coagulopathy, alopecia, stomatitis.	+
-		+
-	==Patient Information==	+
-		+
-	* Instruct patient to take colchicine regularly to prevent acute attacks.	+
-		+
-	* Instruct patient not to exceed 8 mg in course of therapy for acute attack. To minimize cumulative toxicity, patient should wait 3 days before starting second course.	+
-		+
-	* Advise patient with gout to drink at least 2,000 mL of fluid daily, unless contraindicated.	+
-		+
-	* Reinforce health care provider's instructions about weight loss, diet, and alcohol intake.	+
-		+
-	* Advise patient to have extra supply of drug on hand in case health care provider gives instructions to increase dosage.	+
-		+
-	* Instruct patient to stop taking drug if nausea, vomiting, diarrhea, or abdominal pain occurs, especially if patient has history of spastic colon or ulcers.	+

---

Revision as of 00:00, 15 January 2001

Show 3-D Structure

Show 2-D Structure

Colchicine
Systematic (IUPAC) name
4-(dipropylsulfamoyl)benzoic acid;N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl)acetamide
Identifiers
CAS number	?
ATC code	?
PubChem	24848032
Chemical data
Formula	C35H44N2O10S
Mol. mass	684.79626
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Description

General Properties

*Molecular Weight

684.79626

*Molecular Formula

C₃₅H₄₄N₂O₁₀S

*IUPAC NAME

4-(dipropylsulfamoyl)benzoic acid;N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl)acetamide

*Canonical Smiles

CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O.CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

*Isomeric Smiles

N/A

*XLogP

N/A

*Topological Polar Surface Area

158

External Links

• Pubchem

Link to BIAdb Database