Morphine-7,8-oxide
From DrugPedia: A Wikipedia for Drug discovery
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==Description== | ==Description== | ||
| - | + | Increased analgesic activity compared to parent; RN given refers to (5alpha,6alpha,7beta,8beta)-isomer; structure in first source. | |
| + | Morphine-7,8-oxide (morphine epoxide) is assumed to be a metabolite of morphine. Morphine epoxide in antinociceptive action was practically as potent as morphine. The development of tolerance in antinociceptive action was slower in the rats treated with morphine epoxide than in the rats with morphine. Furthermore, morphine epoxide was less potent than morphine in the inhibition of abstinence syndrome. | ||
==General Properties== | ==General Properties== | ||
Revision as of 04:14, 5 May 2009
| Morphine-7,8-oxide
| |
| Systematic (IUPAC) name | |
| N/A | |
| Identifiers | |
| CAS number | ? |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C17H19NO4 |
| Mol. mass | 301.33706 |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Description
Increased analgesic activity compared to parent; RN given refers to (5alpha,6alpha,7beta,8beta)-isomer; structure in first source. Morphine-7,8-oxide (morphine epoxide) is assumed to be a metabolite of morphine. Morphine epoxide in antinociceptive action was practically as potent as morphine. The development of tolerance in antinociceptive action was slower in the rats treated with morphine epoxide than in the rats with morphine. Furthermore, morphine epoxide was less potent than morphine in the inhibition of abstinence syndrome.
General Properties
*Molecular Weight
301.33706
*Molecular Formula
C17H19NO4
*IUPAC NAME
N/A
*Canonical Smiles
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C6C4O6)O
*Isomeric Smiles
CN1CC[C@]23[C@@H]4[C@@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C6C4O6)O
*XLogP
0
*Topological Polar Surface Area
65.5
