Immunotation of Rv0013
From DrugPedia: A Wikipedia for Drug discovery
| Immunotation of Rv0013
| |
| Name | |
| POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) | |
| Identifiers | |
| Swiss Prot | |
| Genbank | |
| PDB | ? |
| Chemical data | |
| Formula | ? |
| Mol. wt. | 24626.9 Da |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Solubility | ? |
| Isoelectric-Point | 6.502 |
Contents |
General
Mb0013, trpG, len: 232 aa. Equivalent to Rv0013, len: 232 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 232 aa overlap). Possible trpG, anthranilate synthase component II (glutamine amidotransferase) (EC 4.1.3.27), equivalent to NP_301141.1|NC_002677 putative p-aminobenzoate synthase glutamine amidotransferase from Mycobacterium leprae (232 aa). Also highly similar to others e.g. P26922|TRPG_AZOBR Anthranilate synthase component II from Azospirillum brasilense (196 aa), FASTA scores: opt: 703, E(): 8.6e-40, (56.7% identity in 187 aa overlap); T36720 probable glutamine amidotransferase from Streptomyces coelicolor (212 aa); T44524 anthranilate synthase from Nitrosomonas europaea (199 aa); etc. Also similar to E235740 para-aminobenzoate synthase (232 aa), FASTA scores: opt: 1273, E(): 0, (79.7% identity in 232 aa overlap). Contains PS00606 Beta-ketoacyl synthases active site; and PS00442 Glutamine amidotransferases class-I active site. SIMILARITY TO OTHER TYPE-1 GLUTAMINE AMIDOTRANSFERASE DOMAINS. Note that previously known as pabA.
MOLECULAR FUNTION
POSSIBLY INVOLVED IN BIOSYNTHESIS OF TRYPTOPHAN (AT THE FIRST STEP). SUPPOSED TETRAMER OF TWO COMPONENTS I AND TWO COMPONENTS II: COMPONENT I (Rv1609|trpE) CATALYZES THE FORMATION OF ANTHRANILATE USING AMMONIA RATHER THAN GLUTAMINE, WHEREAS COMPONENT II (Rv0013|trpG) PROVIDES GLUTAMINE AMIDOTRANSFERASE ACTIVITY. POSSIBLY PARTICIPATES IN THE TRYPTOPHAN-DEPENDENT INDOLE-3-ACETIC ACID PRODUCTION [CATALYTIC ACTIVITY: CHORISMATE + L-GLUTAMINE = ANTHRANILATE + PYRUVATE + L-GLUTAMATE].
Protein Sequence
>M. bovis AF2122/97|Mb0013|TrpG: 232 aa - POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)</b>
MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEA
AVAGQFDGVLLSPGPGTPERAGASVSMVHACAAAHTPLLGV
CLGHQAIGVAFGATVDRAPELLHGKTSSVFHTNVGVLQGLP
DPFTATRYHSLTILPKSLPAVLRVTARTSSGVIMAVQHTGL
PIHGVQFHPESILTEGGHRILANWLTCCGWTQDDTLVRRLE
NEVLTAISPHFPTSTASAGEATGRTSA
Human Homologue Blast Result
| subject ids | % identity | % positives | alignment length | evalue |
| sp|P27708.3| | 29 | 46 | 132 | 1e-08 |
| sp|P49915.1| | 28 | 44 | 112 | 2e-06 |
| sp|P31327.2| | 27 | 42 | 137 | 2e-05 |
| sp|Q92820.2| | 24 | 40 | 123 | 0.33 |
| sp|Q6UW60.1| | 28 | 40 | 75 | 5.5 |
Alergen Protein
Link to Algpred
Non Allergen Predicted by AlgPred Server
Bacterial Toxin Prediction
Link to btxpred
No Hit Fountd by btxpred server.
Subcellular Location
Link to TBpred
Cytoplasmic Protein
Antigens
No Hit Found in AntigenDB
No. Hit Found in IEDB
