PolysacDB Capsular polysaccharide 1004

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Haemophilus influenzae

[edit] Basic Structure

A relatively simple antigen consisting of repeating units of 3-β-D ribose-(1-->1)-D-ribitol-5-phosphate

[edit] Proposed functions

An important virulence determinant

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Neisseria meningitidis group B outer membrane protein complex (Hib PS-OMP)

[edit] Conjugation Method

The strategy uses a oligopeptide spacer molecule whose parts are derived from both modified Haemophilus influenzae capsular polysaccharide and Neisseria meningitides group B outer membrane complex

[edit] Antibodies

Polysera

[edit] Antibody type and class

IgG1 and IgG2

[edit] Assay System

N\A

[edit] Cross-reactivity

N/A

[edit] Proposed epitopes

N\A

[edit] Proposed Utility

These antibodies exert their protective effect by initiating complement-mediated activities including opsonization and bacterial lysis

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database