PolysacDB 2475

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Excretory-secretory antigen [ES]

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Toxocara canis

[edit] Basic Structure

Excretory-secretory (ES) antigens of this species are composed of a restricted range of components, with overlapping but not identical profiles. The ES antigens range in m.w. from 32,000 (32 KDa) to 400 KDa and include at least one allergenic component. They are each glycoproteins, containing in all 40% by weight of carbohydrate, and differential lectin binding and protease sensitivity indicate that the major components are discrete parasite antigens rather than degradation products of common derivation

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

T. canis larvae

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab Tcn-5

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunoblotting, immunofluorescence, Immunoradiometric assay and inhibition assay

[edit] Cross-reactivity

This Mab cross-reacted and showed positive reactions to surface and ES antigens of T. cati, but did not react with surface-labeled antigens of the nematodes T.spiralis, Heligmososmoides polygyrus. or B. pahangi

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used for elucidating the biological functions of the secreted glycoproteins in an attempt to define the molecular parameters of toxocaral parasitism and pathogenesis

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database