Mestranol
From DrugPedia: A Wikipedia for Drug discovery
Mestranol Pubchem(6291) The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.
KEGG(C07618,D00575)
Activity Estrogen
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 150.5 | deg C | EXP | |
| log P (octanol-water) | 4.680 | (none) | EST | |
| Atmospheric OH Rate Constant | 9.04E-11 | cm3/molecule-sec | 25 | EST |
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |mouse |LD50 |intraperitoneal |> 3200mg/kg (3200mg/kg) |SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |mouse |LD50 |oral |> 10gm/kg (10000mg/kg) |SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |mouse |LD50 |subcutaneous |2500mg/kg (2500mg/kg) |SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |intraperitoneal |> 3gm/kg (3000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |oral |> 10gm/kg (10000mg/kg) | |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |subcutaneous |> 5gm/kg (5000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |-
