20-Hydroxyecdysone
From DrugPedia: A Wikipedia for Drug discovery
Ecdysterone
Pubchem(5459840,3032482)
A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.
KEGG Pathway(C02633)
- Insect hormone biosynthesis
MMDB ID | PDB ID | Reference |
---|---|---|
59627 | 2R40 | Browning C, Martin E, Loch C, Wurtz JM, Moras D, Stote RH, Dejaegere AP, Billas IMCritical Role of Desolvation in the Binding of 20-Hydroxyecdysone to the Ecdysone ReceptorJ. Biol. Chem. v282, p.32924-32934 |
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 6400mg/kg (6400mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 551, 1970. | |
mouse | LD50 | oral | > 9gm/kg (9000mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 66, Pg. 551, 1970. |