CarboDB Lipoarabinomannan 1036

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1 Carbohydrate Name
2 Carbohydrate Class
3 Source Microbe
4 Basic Structure
5 Proposed functions
6 Antigenic Nature used to produce antibodies
7 Carrier Name
8 Conjugation Method
9 Antibodies
10 Antibody type and class
11 Assay System
12 Cross-reactivity
13 Proposed epitopes
14 Proposed Utility
15 Weblink
16 External Links

Carbohydrate Name

Lipoarabinomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium leprae

Basic Structure

Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor

Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

Antigenic Nature used to produce antibodies

whole killed mycobacteria leprae cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab Cs-35

Antibody type and class

IgM

Assay System

Indirect and Competitive ELISA

Cross-reactivity

This antibody cross-reacted to M. tuberculosis and other Mycobacterium speices.

Proposed epitopes

β-D-Araf- (1-->2)-α-D-Araf-(1-->5)-α- D-Araf-(1-->5)-α-D-Araf within the branched hexa-Araf motif of mycobacterial arabinans

Proposed Utility

These antibodies could be used for screening of cell-wall mutants of mycobacteria lacking AG and AraLAM motifs and the recognition of biosynthetic intermediates of cell-wall polysaccharides unique to mycobacteria.