CarboDB Phenolic glycolipid-I 1729

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Phenolic glycolipid-I

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium leprae

Basic Structure

Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose

Proposed functions

It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy

Antigenic Nature used to produce antibodies

Phenolic glycolipid-1 and heat-killed M. leprae

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab VI703

Antibody type and class

IgG3

Assay System

ELISA

Cross-reactivity

This Mab reacted with deacylated Phenolic glycolipid-1[ PGL-I (PGL-I OH )], but did not bind to PGL antigens from M. kansasii (mycoside A), M. bovis (deacylated mycosideB), and M. tuberculosis (PGL-Tb OH )

Proposed epitopes

The outer monosaccharide, disaccharide and the trisaccharide all contributed to the epitope recognized by this Mab

Proposed Utility

This Mab was used for the development of peptide mimotopes resembling the carbohydrate structures recognized by this Mab

Weblink

PubMed

External Links

• IEDB Epitopic Detail

• Link to CarboDB database