PolysacDB Lipoarabinomannan 1007

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoarabinomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium tuberculosis

Basic Structure

Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues, and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor

Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

Antigenic Nature used to produce antibodies

Heat killed Mycobacterium tuberculosis

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 5c11

Antibody type and class

IgM

Assay System

Indirect immunofluorescence, ELISA, western blotting

Cross-reactivity

This antibody cross-reacted with large number of mycobacterial species.

Proposed epitopes

Arabinose moiety of Lipoarabinomannan

Proposed Utility

This antibody has been used in the detection of mycobacteria in clinical samples

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database