PolysacDB Capsular polysaccharide 1971

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Streptococcus pneumoniae strain 6B

Basic Structure

The capsular polysaccharide consists of the following residues : -2)-α-D-Galp-(1-->3)-α-D-Glcp-(1-->3)-α-L-Rhap-(1-->4)-D-Rib-ol-(5-P-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

The oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid

Antibodies

Mab 10H8

Antibody type and class

IgG1

Assay System

Enzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay

Cross-reactivity

This Mab reacted with polysaccharides from 11A, 19F and 23F strain but did not recognize type 6A polysaccharide

Proposed epitopes

disaccharide rhamnose-(1-->4)-ribitol phosphate residues seemed to be the part of the epitope

Proposed Utility

N/A

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database