PolysacDB Lipopolysaccharide 2325

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Shigella flexneri [polyvalent S. flexneri 2a/3a vaccine (CVD 1207/CVD 1211)]

Basic Structure

Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Antisera

Antibody type and class

IgA

Assay System

ELISA

Cross-reactivity

This antisera showed an extensive cross-reaction that included S. flexneri serotypes 1a, 1b, 2b, 4b, 5b, and Y

Proposed epitopes

N/A

Proposed Utility

Cross-protection was observed among S. flexneri serotypes elicited by the S. flexneri 2a/3a vaccine

Weblink

PubMed Central

External Links

• Link to PolysacDB database