Mestranol

From DrugPedia: A Wikipedia for Drug discovery

Mestranol Pubchem(6291) The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.

KEGG(C07618,D00575)

Activity Estrogen

Physical Property Value Units Temp (deg C) Source |Melting Point |150.5 |deg C | |EXP |- |log P (octanol-water) |4.680 |(none) | |EST |- |Atmospheric OH Rate Constant |9.04E-11 |cm3/molecule-sec |25 |EST |- Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |mouse |LD50 |intraperitoneal |> 3200mg/kg (3200mg/kg) |SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |mouse |LD50 |oral |> 10gm/kg (10000mg/kg) |SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |mouse |LD50 |subcutaneous |2500mg/kg (2500mg/kg) |SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |intraperitoneal |> 3gm/kg (3000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |oral |> 10gm/kg (10000mg/kg) | |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |- |rat |LD50 |subcutaneous |> 5gm/kg (5000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER |Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 217, 1970. |-