Ecdysone

From DrugPedia: A Wikipedia for Drug discovery

alpha-Ecdysone

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster, an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form. Ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have medicinal valueTemplate:Fact and are part of herbal adaptogenic remedies like Cordyceps. A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids. Pubchem(19212)

A steroid hormone that regulates the processes of MOLTING or ecdysis in insects.

KEGG Pathway(C00477) Insect hormone biosynthesis

See also

• Ecdysone receptor

External links

• Ecdybase, The Ecdysone Handbook - a free online ecdysteroids databaseTemplate:Arthropod-stub