Bordetella bronchiseptica
From DrugPedia: A Wikipedia for Drug discovery
Bordetella bronchiseptica
Bordetella bronchiseptica is a small, gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious bronchitis, but rarely infects humans. Closely related to B. pertussis—the obligate human pathogen that causes pertussis or whooping cough—B. bronchiseptica can persist in the environment for extended periods
| Kingdom | Bacteria |
|---|---|
| Phylum | Proteobacteria |
| Class | Beta proteobacteria |
| Order | Burkholderiales |
| Family | Alcaligenaceae |
| Genus | Bordetella |
| Species | B. bronchiseptica |
| Binomial | Bordetella bronchiseptica |
Surface Characteristics
It consists of a characteristic lipopolysaccharide [LPS] on its outer surface. The O-chain of these bacteria was reported as a homopolymer of 1,4-linked 2,3-diacetamido-2,3- dideoxy-α-galacturonic acid. This polymer contains several amidated uronic acids, the number of which varies between strains
Pathogenic Activity
In veterinary medicine, B. bronchiseptica leads to a range of pathologies in different hosts. It is a serious disease of dogs, pigs, and rabbits and has been seen in cats, horses, and seals. There is a PCR test for the pathogen. In pigs, B. bronchiseptica and Pasteurella multocida act synergistically to cause atrophic rhinitis, a disease resulting in arrested growth and distortion of the turbinates in the nasal terminus (snout). In dogs, B. bronchiseptica causes acute tracheobronchitis, which typically has a harsh, honking cough. (See kennel cough). Kennel cough can also be caused by canine adenovirus-2 or canine parainfluenza virus or a combination of pathogens. In rabbits, B. bronchiseptica is often found in the nasal tract. It is often assumed to cause a nearly asymptomatic infection known as snuffles, but the causative agent for that disease is Pasteurella multocida; "B. bronchiseptica" often co-infects the nasal passage at the same time. Humans are not natural carriers of B. bronchiseptica
