PolysacDB Glucurunoxylomannan 1013

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Glucurunoxylomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Cryptococcus neoformans serotype A

Basic Structure

The GXM backbone consists of a linear α(1-->3)-linked mannan substituted at 2-O positions by single residues of either xylose or glucuronic acid

Proposed functions

Antiphagocytic ; an important virulence factor

Antigenic Nature used to produce antibodies

Pure Capsular polysaccharide

Carrier Name

N/A

Conjugation Method

N/A

Antibodies

Mab E1

Antibody type and class

IgG1

Assay System

Agglutination with C. neoformans serotype A cells, Radial immunodiffusion, Indirect Immunofluorescence,, ELISA, Competitive binding assays

Cross-reactivity

This antibody was highly specific to serotype A, low levels of cross reactivity to serotypes B and D. Among the other yeasts tested, a cross-reaction was only detected with Trichosporon beigelii.

Proposed epitopes

N\A

Proposed Utility

could be useful for fundamental studies on the glucuronoxylomannan structure, as well as for clinical applications such as serotyping and possibly the serological diagnosis of cryptococcosis

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database