PolysacDB Capsular polysaccharide 1022

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Cryptococcus neoformans

[edit] Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

[edit] Proposed functions

The capsular polysaccharide is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Cryptococci cells

[edit] Carrier Name

N/A

[edit] Conjugation Method

N/A

[edit] Antibodies

Mab 20B5

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody was specific to D serotype and cross-reacted with GH strain

[edit] Proposed epitopes

N\A

[edit] Proposed Utility

This antibody was shown to bind to cryptococcal capsule

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database