PolysacDB 1798

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

N-propionylated α(2-->8)-linked sialooligosaccharides

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Neisseria meningitidis

[edit] Basic Structure

N-propionylated α(2-->8)-linked sialooligosaccharides

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Tetanus toxoid

[edit] Conjugation Method

The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days

[edit] Antibodies

Mab 7C11

[edit] Antibody type and class

IgG1

[edit] Assay System

ELISA, bactericidal assays

[edit] Cross-reactivity

N/A

[edit] Proposed epitopes

The epitope was located on short internal fragments of the polysaccharide

[edit] Proposed Utility

This Mab would help in the elucidation of the capsular polysaccharide structure

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database