Ethinyl Estradiol
From DrugPedia: A Wikipedia for Drug discovery
Ethinyl Estradiol Pubchem(5991)
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
KEGG PATHWAY(C07534,D00554)
Category Hormone
Activity Estrogen
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 183 | deg C | EXP | |
| log P (octanol-water) | 3.67 | (none) | EXP | |
| Water Solubility | 11.3 | mg/L | 27 | EXP |
| Vapor Pressure | 2.67E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 7.94E-12 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.25E-10 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 250mg/kg (250mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| mouse | LD50 | oral | 950mg/kg (950mg/kg) | Drugs in Japan Vol. -, Pg. 222, 1995. | |
| mouse | LD50 | subcutaneous | > 3gm/kg (3000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | BLOOD: HEMORRHAGE Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| rat | LD50 | intraperitoneal | 471mg/kg (471mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| rat | LD50 | oral | 960mg/kg (960mg/kg) | Drugs in Japan Vol. -, Pg. 222, 1995. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: HEMORRHAGE | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18, Pg. 2583, 1990. |
| women | TDLo | oral | 21mg/kg/21D-I (21mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: NAUSEA OR VOMITING | Lancet. Vol. 1, Pg. 1479, 1973. |
