PolysacDB Glycoprotein GP72 2487

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Glycoprotein GP72

Carbohydrate Class

Miscellaneous

Source Microbe

Trypanosoma cruzi Z2 Esmeraldo/3

Basic Structure

GP72 is a 72-kilodalton cell surface glycoprotein found on epimastigotes and metacyclic trypomastigotes

Proposed functions

GP72 may regulate T. cruzi morphogenesis in the insect vector

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab WIC 29.26

Antibody type and class

IgG2a

Assay System

ELISA, immunoblotiing, indirect immunofluorescence

Cross-reactivity

This Mab cross-reacted with T. cruzi BOL Z2, and Z3 but did not react with Z1. WIC 29.26 bound to only 2 of the 4 Trypanozome cruzi strains and 23 of the 50 clones tested

Proposed epitopes

WIC 29.26 binds to phosphorylated sugar side chains, which comprise 85% of GP72 carbohydrate and contain ribose, xylose, and fucose

Proposed Utility

Anti-T. cruzi monoclonal antibodies are considered to have important applications to epidemiological studies and the improved diagnosis and prognosis of Chagas' disease

Weblink

PubMed

External Links

• Link to PolysacDB database